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Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
Around the similar time, the group of Paul McEuen, who was then based for the University of California, Berkeley, confirmed related outcomes on ropes of bundled nanotubes. Based on the wrapping angle, nanotubes can are available metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed applying scanning tunnelling spectroscopy experiments.
Deposition and atomic drive microscopy of unique phthalocyanine polymers concerning nanofabricated electrodes
2010, designed a different way (‘wedging transfer’) to govern nanostructures; first report of DNA translocation via graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into reliable-point out nanopores
Our investigation ranges in the biophysics of DNA to synthetic cells and past. Remember to have a look under with the spectrum of our recent initiatives.
We use nanofabricated microfluidic constructions to pattern spatial boundaries for microorganisms and biomimetic vesicles with reconstituted protein networks and this assess the elemental job of spatial confinement within the molecular and mobile stage. Our initiatives incorporate the next:
Dynamic cees dekker ParB–DNA interactions initiate and preserve a partition condensate for bacterial chromosome segregation
‘You shouldn't just contemplate the issues of tomorrow, but will also evaluate the issues of your working day just after tomorrow’
But carbon nanotubes have remained a research subject matter of sizeable fascination to a lot of. Without a doubt, the outlook on employing carbon nanotubes to develop functional units, in locations like radio-frequency electronics, electronic electronics and versatile electronics, stays vibrant.
Since 2000 he moved to solitary-molecule biophysics and nanobiology, with study from experiments of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more not long ago his analysis has centered on learning chromatin composition and cell division with microbes on chip, although he is usually trying to finally Construct artificial cells from the bottom up.
Cees Dekker is Distinguished College Professor at TU Delft. Qualified being a physicist, he pioneered nanotechnology with quite a few discoveries on carbon nanotubes from the nineties. Considering that 2000, he moved to solitary-molecule biophysics and nanobiology. His existing analysis focuses on (i) nanopores for protein sequencing; (ii) chromosome structure, especially SMC motor protein; and (iii) developing a residing synthetic cell from lifeless molecules. Dekker is an elected member from the KNAW and fellow towards the APS and the IOP.
2008, to start with observation of protein-coated DNA translocation as a result of nanopores; fixed the origin with the electrophoretic pressure on DNA in nanopores; uncovered a major velocity enhance of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
2013, controlled shaping of live bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations inside the handedness of histone tetrasomes